منابع مشابه
A membrane bending model of outer hair cell electromotility.
We propose a new mechanism for outer hair cell electromotility based on electrically induced localized changes in the curvature of the plasma membrane (flexoelectricity). Electromechanical coupling in the cell's lateral wall is modeled in terms of linear constitutive equations for a flexoelectric membrane and then extended to nonlinear coupling based on the Langevin function. The Langevin funct...
متن کاملOptogenetic Control of Mouse Outer Hair Cells.
Normal hearing in mammals depends on sound amplification by outer hair cells (OHCs) presumably by their somatic motility and force production. However, the role of OHC force production in cochlear amplification and frequency tuning are not yet fully understood. Currently, available OHC manipulation techniques for physiological or clinical studies are limited by their invasive nature, lack of pr...
متن کاملEffect of Outer Hair Cell Membrane Piezoelectric Frequency Conditions
Abstraa-We have found that the hand pass characteristics of the cochlear outer hair cell can he improved by introducing the piezoelectric properties of the cell membrane. In contrast to the conventional analysis, the cell membrane receptor potential does not tend to zero and at any frequency is greater than a limiting value. The piezoelectric properties cause an additional, strain-dependent, di...
متن کاملTuning of the outer hair cell motor by membrane cholesterol.
Cholesterol affects diverse biological processes, in many cases by modulating the function of integral membrane proteins. We observed that alterations of cochlear cholesterol modulate hearing in mice. Mammalian hearing is powered by outer hair cell (OHC) electromotility, a membrane-based motor mechanism that resides in the OHC lateral wall. We show that membrane cholesterol decreases during mat...
متن کاملCochlear amplification, outer hair cells and prestin.
Mechanical amplification of acoustic signals is apparently a common feature of vertebrate auditory organs. In non-mammalian vertebrates amplification is produced by stereociliary processes, related to the mechanotransducer channel complex and probably to the phenomenon of fast adaptation. The extended frequency range of the mammalian cochlea has probably co-evolved with a novel hair cell type, ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2021
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2020.11.017